Original articles in indexed journals - PharmacoInformatics - GPCR Drug Discovery

Jung C, Gené GG, Tomás M, Plata C, Selent J, Pastor M, Fandos C, Senti M, Lucas G, Elosua R, Valverde MA. A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction. Cardiovasc Res, 2011; 91(3): 465-71 . PMID: 21427121 . DOI: 10.1093/cvr/cvr083.

2011

Original articles in indexed journals - PharmacoInformatics - GPCR Drug Discovery

Obiol-Pardo C. López L, Pastor M, Selent J. Progress in the structural prediction of G protein-coupled receptors: D3 receptor in complex with eticlopride. Proteins, 2011; 79 (6): 1695-1703 . PMID: 21491496 . DOI: 10.1002/prot.23021.

2011

Original articles in indexed journals - PharmacoInformatics

Blasi D, Pinto M, Nieto J, Arsequell G, Valencia G, Planas A, Centeno NB, Quintana J. Drug discovery targeted at transthyretin cardiac amyloidosis: rational design, synthesis, and biological activity of new transthyretin amyloid inhibitors. Amyloid, 2011;18 Suppl 1:55-57 . PMID: 21838431 .

2011

Original articles in indexed journals - PharmacoInformatics

Pinto M, Blasi D, Nieto J, Arsequell G, Valencia G, Planas A, Quintana J, Centeno NB. Ligand-binding properties of human transthyretin. Amyloid, 2011;18 Suppl 1:46-9. PMID: 21838430 . DOI: 1,433.

2011

Original articles in indexed journals - PharmacoInformatics

Blasi D, Arsequell A, Valencia G, Nieto J, Planas A, Pinto M, Centeno NB, Abad-Zapatero C, Quintana J. Retrospective Mapping of SAR Data for TTR Protein in Chemico-Biological Space Using Ligand Efficiency Indices as a Guide to Drug Discovery Strategies. Molecular Informatics, 2011. 30(2-3):161-167. PMID: 21838431 . DOI: 10.1002/minf.201000157.

2011

Original articles in indexed journals - Integrative Biomedical Informatics - PharmacoInformatics

Obiol-Pardo C, Gomis-Tena J, Sanz F, Saiz J, Pastor M. A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity. Journal of Chemical Information and Modeling, 2011. 51(2):483-92. PMID: 21250697 . DOI: 10.1021/ci100423z.

2011

Original articles in indexed journals - PharmacoInformatics - GPCR Drug Discovery

Novensa L, Selent J, Pastor M, Sandberg K, Heras M, Dantas P. Equine Estrogens Impair Nitric Oxide Production and Endothelial Nitric Oxide Synthase Transcription in Human Endothelial Cells Compared With the Natural 17{beta}-Estradiol. Hypertension, 2010. 56 (3); 405-U140 . PMID: 20606108 . DOI: 10.1161/HYPERTENSIONAHA.110.151969.

2010

Original articles in indexed journals - Integrative Biomedical Informatics - PharmacoInformatics - Computational Science - GPCR Drug Discovery

Selent J, Sanz F, Pastor M, de Fabritiis G. Induced effects of sodium ions on dopaminergic G-protein coupled receptors. PLoS Comput Biol 2010; 6(8): e1000884. . PMID: 20711351 . DOI: 10.1371/journal.pcbi.1000884.

2010

Original articles in indexed journals - Integrative Biomedical Informatics - PharmacoInformatics - GPCR Drug Discovery

Lopez-Muñoz L, Selent J, Ortega R, Masaguer CF, Domínguez E, Areias F, Brea J, Loza MI, Sanz F, Pastor M. Synthesis, 3D-QSAR, and Structural Modeling of Benzolactam Derivatives with Binding Affinity for the D(2) and D(3) Receptors. ChemMedChem 2010; 5(8): 1300-1317. . PMID: 20544783 . DOI: 10.1002/cmdc.201000101.

2010

Original articles in indexed journals - Integrative Biomedical Informatics - PharmacoInformatics - GPCR Drug Discovery

Selent J, Bauer-Mehren A, Lopez L, Loza MI, Sanz F, Pastor M. A Novel Multilevel Statistical Method for the Study of the Relationships between Multireceptorial Binding Affinity Profiles and In Vivo Endpoints. Molecular Pharmacology, 2010; 77 (2): 149-158 . PMID: 19903829 . DOI: 10.1124.

2010