Original articles in indexed journals - GPCR Drug Discovery

Jobin ML, De Smedt-Peyrusse V, Ducrocq F, Baccouch R, Oummadi A, Pedersen MH, Medel-Lacruz B, Angelo MF, Villette S, Van Delft P, Fouillen L, Mongrand S, Selent J, Tolentino-Cortez T, Barreda-Gómez G, Grégoire S, Masson E, Durroux T, Javitch JA, Guixà-González R, Alves ID, Trifilieff P. Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Mol Psychiatry, 2023. PMID: 36604603 . DOI: 10.1038/s41380-022-01928-6.

2023

Original articles in indexed journals - GPCR Drug Discovery

Baidya M, Chaturvedi M, Dwivedi-Agnihotri H, Ranjan A, Devost D, Namkung Y, Stepniewski TM, Pandey S, Baruah M, Panigrahi B, Sarma P, Yadav MK, Maharana J, Banerjee R, Kawakami K, Inoue A, Selent J, Laporte SA, Hébert TE, Shukla AK. Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody. Nat Commun, 2022; 13(1): 4634. PMID: 35941121 . DOI: 10.1038/s41467-022-32386-x.

2022

Original articles in indexed journals - GPCR Drug Discovery

Morales-Pastor A, Nerín-Fonz F, Aranda-García D, Dieguez-Eceolaza M, Medel-Lacruz B, Torrens-Fontanals M, Peralta-García A, Selent J. In Silico Study of Allosteric Communication Networks in GPCR Signaling Bias. Int J Mol Sci, 2022; 23(14): 7809. PMID: 35887157 . DOI: 10.3390/ijms23147809.

2022

PhD Thesis - Integrative Biomedical Informatics - GPCR Drug Discovery

Torrens Fontanals, M. Making protein dynamics FAIR: Research platforms for the collection, dissemination, and analysis of molecular dynamics simulations. Universitat Pompeu Fabra. February, 11th 2022. Thesis Directors: Sanz F, Selent J.

2022

Original articles in indexed journals - GPCR Drug Discovery

Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov KA, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DE. Community guidelines for GPCR ligand bias: IUPHAR review 32. Br J Pharmacol, 2022. PMID: 35106752 . DOI: 10.1111/bph.15811.

2022

Original articles in indexed journals - GPCR Drug Discovery

Torrens-Fontanals M, Peralta-García A, Talarico C, Guixà-González R, Giorgino T, Selent J. SCoV2-MD: a database for the dynamics of the SARS-CoV-2 proteome and variant impact predictions. Nucleic Acids Res, 2022; 50(D1): D858-D866. PMID: 34761257 . DOI: 10.1093/nar/gkab977.

2022

Original articles in indexed journals - GPCR Drug Discovery

Peralta-Garcia A, Torrens-Fontanals M, Stepniewski TM, Grau-Expósito J, Perea D, Ayinampudi V, Waldhoer M, Zimmermann M, Buzón MJ, Genescà M, Selent J. Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells. Int J Mol Sci, 2021; 22(24):13592. PMID: 34948390 . DOI: 10.3390/ijms222413592.

2021

Original articles in indexed journals - GPCR Drug Discovery

Giubilaro J, Schuetz DA, Stepniewski T, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA*. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nat Commun 2021; 12(1): 4688. PMID: 34344896 . DOI: 10.1038/s41467-021-24968-y.

2021

Original articles in indexed journals - GPCR Drug Discovery

Stepniewski TM, Mancini A, Agren R, Torrens-Fontanals M, M Semache, Bouvier M, Sahlholm K, Breton B, Selent J . Mechanistic insights into dopaminergic and serotonergic neurotransmission-concerted interactions with helices 5 and 6 drive the functional outcome. Chem Sci, 2021; 2; 12(33): 10990-11003.. PMID: 34522296 . DOI: 10.1039/D1SC00749A.

2021

Original articles in indexed journals - GPCR Drug Discovery

Kumar GA, Sarkar P, Stepniewski T, Jafurulla M, Singh SP, Selent J*, Chattopadhyay A*. A molecular sensor for cholesterol in the human serotonin 1A receptor. Sci Adv 2021; 7(30): eabh2922. PMID: 34301606 . DOI: 10.1126/sciadv.abh2922.

2021