Original articles in indexed journals - PharmacoInformatics - GPCR Drug Discovery

Fernandez-Mariño AI, Porras-González C, Gonzalez-Rodriguez P, Selent J, Pastor M, Ureña J, Castellano A, Valverde MA, Fernández-Fernández JM. Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation. Cardiovasc Res. 2012. . PMID: 22473360 . DOI: 10.1093/cvr/cvs139.

2012

Original articles in indexed journals - Integrative Biomedical Informatics - PharmacoInformatics

Briggs K, Cases M, Heard DJ, Pastor M, Pognan F, Sanz F, Schwab CH, Steger-Hartmann T, Sutter A, Watson DK, Wichard JD. Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project. Int J Mol Sci, 2012; 13(3), 3820-3846.. PMID: 22489185 . DOI: 10.3390/ijms13033820.

2012

Original articles in indexed journals - PharmacoInformatics

Rosa M, Arsequell G, Rougeot C, Calle LP, Marcelo F, Pinto M, Centeno NB, Jiménez-Barbero J, Valencia G. Structure-Activity Relationship Study of Opiorphin, a Human Dual Ectopeptidase Inhibitor with Antinociceptive Properties. J Med Chem, 2012;55(3):1181-8. PMID: 22224710 . DOI: 10.1021/jm2012112.

2012

Original articles in indexed journals - PharmacoInformatics

Pinto M, Rougeot C, Gracia L et al (including Centeno NB). Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS, 2012; 3; 1: 20-24 DOI: 10.1021/ml200182v.

2012

Original articles in indexed journals - PharmacoInformatics - GPCR Drug Discovery

Jung C, Gené GG, Tomás M, Plata C, Selent J, Pastor M, Fandos C, Senti M, Lucas G, Elosua R, Valverde MA. A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction. Cardiovasc Res, 2011; 91(3): 465-71 . PMID: 21427121 . DOI: 10.1093/cvr/cvr083.

2011

Original articles in indexed journals - PharmacoInformatics - GPCR Drug Discovery

Obiol-Pardo C. López L, Pastor M, Selent J. Progress in the structural prediction of G protein-coupled receptors: D3 receptor in complex with eticlopride. Proteins, 2011; 79 (6): 1695-1703 . PMID: 21491496 . DOI: 10.1002/prot.23021.

2011

Original articles in indexed journals - PharmacoInformatics

Blasi D, Pinto M, Nieto J, Arsequell G, Valencia G, Planas A, Centeno NB, Quintana J. Drug discovery targeted at transthyretin cardiac amyloidosis: rational design, synthesis, and biological activity of new transthyretin amyloid inhibitors. Amyloid, 2011;18 Suppl 1:55-57 . PMID: 21838431 .

2011

Original articles in indexed journals - PharmacoInformatics

Pinto M, Blasi D, Nieto J, Arsequell G, Valencia G, Planas A, Quintana J, Centeno NB. Ligand-binding properties of human transthyretin. Amyloid, 2011;18 Suppl 1:46-9. PMID: 21838430 . DOI: 1,433.

2011

Original articles in indexed journals - PharmacoInformatics

Blasi D, Arsequell A, Valencia G, Nieto J, Planas A, Pinto M, Centeno NB, Abad-Zapatero C, Quintana J. Retrospective Mapping of SAR Data for TTR Protein in Chemico-Biological Space Using Ligand Efficiency Indices as a Guide to Drug Discovery Strategies. Molecular Informatics, 2011. 30(2-3):161-167. PMID: 21838431 . DOI: 10.1002/minf.201000157.

2011

Original articles in indexed journals - Integrative Biomedical Informatics - PharmacoInformatics

Obiol-Pardo C, Gomis-Tena J, Sanz F, Saiz J, Pastor M. A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity. Journal of Chemical Information and Modeling, 2011. 51(2):483-92. PMID: 21250697 . DOI: 10.1021/ci100423z.

2011