06/07/2021

Thesis defence of Joaquim Aguirre: ​"​In silico tools to study diseases and polypharmacology through the lens of network medicine​"​

​Next ​Wednesday, 14th of July​ at ​11​:​00, ​Joaquim Aguirre, member of the Structural Bioinformatics group of GRIB will read his thesis ​​"​In silico tools to study diseases and polypharmacology through the lens of network medicine​

The event will be online. Free access at https://us02web.zoom.us/j/83124036086​

Abstract:   

The inner workings of cells can be understood as an interplay of interactions between biomolecules, forming a network known as the interactome. Drugs and diseases can be considered as perturbations in this network, modulating directly specific molecules, but indirectly communities of molecules whose interactions are affected by the perturbation. Network medicine seeks to accurately represent and analyze biological networks to understand diseases and find safer and more effective treatments. In this thesis, I present several in silico tools for network medicine, addressed to study the molecular mechanisms of diseases and drugs. These tools are used in a wide range of novel and diverse applications of network medicine, such as the study of comorbidities, endophenotypes, side effects, drug combinations and drug repurposing.