26/01/2015

Thesis defence of Jaume Bonet: "Exploiting protein fragments in protein modelling and function prediction"

On 30^rd of January, Jaume Bonet, member of the Structural Bioinformatics group of GRIB (IMIM-UPF) will defend his thesis at 11:00 at Josep Marull Room (QMAR building). You are all invited to this event.

ABSTRACT:

Proteins are the basic functional and structural blocks of life. Knowledge of their structure and function is key to understand how it works. Lately, the gap between new discovered proteins and systematically studied ones has increased due to the advance of sequencing techniques. As experimental methods are not able to keep up with the growing data, computational approximations to fill that gap are required. This thesis presents the study of protein loops (aperiodic regions in their three dimensional conformation) and their computational applications. It describes the latest developments regarding their classification (ArchDB), their use in protein structure modelling (Frag’r’Us) and in protein function prediction (Archer). It takes a special focus in protein redesign, which can be exploited to produce catalyst for non-biological processes or to design new synthetic biology pathways.