06/10/2014

OncodriveROLE predicts activating and loss of function cancer driver genes

The Biomedical Genomics group of GRIB announce a new member of the Oncodrive methods family: OncodriveROLE, an approach to classify cancer drivers into loss of function and activating roles. OncodriveROLE joins and complements the previously developed methods that identify cancer driver genes from the list of somatic mutations in cohort of tumors (OncodriveCLUST and OncodriveFM).

The manuscript describing OncodriveROLE is now published in Bioinformatics and freely available online. The method has been presented in a talk at the ECCB meeting in Strasbourg in September. 

Article Ref: Schroeder MP, Rubio-Perez C, Tamborero D, Gonzalez-Perez A, Lopez-Bigas N. OncodriveROLE classifies cancer driver genes in loss of function and activating mode of action. Bioinformatics, 2014; 30(17):i549-i555.